Description: This antibody recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. In Hodgkin’s disease, it is expressed by mononuclear- Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the majority of anaplastic large cell lymphomas as well as by some activated T and B cells. This antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).